ROR1 APC
Catalog #
Size
Price
| Conjugation | APC |
|---|---|
| Antigen | ROR1 |
| Clone | 19925R |
| Isotype | IgG1, k |
| Applications | FC |
| Reactivity | Human |
| Host | Mouse |
| Clonality | Monoclonal |
| Primary/Secondary | Primary |
| Format | 0.09% sodium azide, 0.2% BSA (w/v), PBS pH 7.2 |
| Storage | 2-8°C |
| Status | RUO |
| Excitation Laser | Red (633nm) |
Description:
Receptor tyrosine kinase-like orphan receptor 1 (ROR1), also referred to as NTRKR1, is a type I transmembrane protein belonging to the ROR subfamily of cell surface receptors. Structurally, ROR1 includes a frizzled-like domain, an immunoglobulin-like C2-type domain, a kringle domain, and a pseudokinase domain lacking enzymatic function. ROR1 is predominantly expressed in embryonic tissues, the central nervous system, and certain cancer cells. It is notably used as a biomarker for B-cell chronic lymphocytic leukemia. Wnt5a has been identified as a ligand that interacts with ROR1. Growing research supports the role of abnormal ROR1 expression in the development of various human cancers.
Receptor tyrosine kinase-like orphan receptor 1 (ROR1), also referred to as NTRKR1, is a type I transmembrane protein belonging to the ROR subfamily of cell surface receptors. Structurally, ROR1 includes a frizzled-like domain, an immunoglobulin-like C2-type domain, a kringle domain, and a pseudokinase domain lacking enzymatic function. ROR1 is predominantly expressed in embryonic tissues, the central nervous system, and certain cancer cells. It is notably used as a biomarker for B-cell chronic lymphocytic leukemia. Wnt5a has been identified as a ligand that interacts with ROR1. Growing research supports the role of abnormal ROR1 expression in the development of various human cancers.
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