Lymphocytes gated PMA stimulated fixed and permeabilized PBMCs intracellularly stained with Perforin (B-D48) PE (RED); Lymphocytes gated PMA stimulated fixed and permeabilized PBMCs are used as FMO control (BLUE).
The clone B-D48, a mouse monoclonal antibody selectively recognizes ~70 KDa cytoplasmic cytotoxic granules pore-forming protein known as Perforin. Perforin is primarily expressed in the cytoplasm of cytotoxic T lymphocytes (CTLs) and natural killer (NK) cells through which these cells perform their anti-viral and antitumor killing activities.
CBI produces and conjugates all of its own antibodies. Each antibody is rigorously validated specifically for flow cytometry applications in an ISO9001 / ISO 13485 certified facility. CBI conjugates FITC; PE; PerCP; APC; Biotin; PerCP-Cyanine 5.5; PE- Cyanine 7, APC-Cyanine 7 and a variety of other fluorophores. Recently, CBI has partnered with AAT Bioquest®, a producer of fluorescent labeling dyes to offer a unique high-performance solution for immunophenotyping and immunomonitoring.
iFluor™ Dyes iFluor™ dyes span the full UV-visible-IR spectrum. iFluor™ dyes have improved labeling performance compared to the classic fluorescent labeling dyes such as FITC, TRITC, Texas Red® and cyanine dyes
mFluor™ Dyes mFluor™ dyes span the full UV-visible spectrum and designed to be maximally excited by one of the major light sources in flow cytometers such as the violet laser at 405 nm or blue laser at 488 nm.
Monoclonal antibody design and development is lending researchers the opportunity to create highly specific, customizable mAbs for both RUO and ASR purposes. Start with a free consultation and let us take it to the step of your choosing.
Choose the production quantity that best meets your needs:From Idea to Antibody
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