The clone 4H11, a mouse monoclonal antibody recognizes a human ~115 KDa monomeric transmembrane phosphoglycoprotein commonly known as CD34. It is expressed mostly on hematopoietic progenitors and pluripotent stem cells, and in multitude of other nonhematopoietic cell types including muscle satellite cells, corneal keratocytes, interstitial cells, epithelial progenitors, and vascular endothelial progenitors.
The anti-CD34 binding affinity has been assigned to three classes (class I, II or III) based on their neuraminidase and glycoprotease sensitivity response and 4H11 is considered as class III antibody. In clinical practice, CD34 expression is evaluated to ensure rapid engraftment in BM transplants and can also be used as a selective marker in cell sorting to enrich a population of immature hematopoietic cells.
CBI produces and conjugates all of its own antibodies. Each antibody is rigorously validated specifically for flow cytometry applications in an ISO9001 / ISO 13485 certified facility. CBI conjugates FITC; PE; PerCP; APC; Biotin; PerCP-Cyanine 5.5; PE- Cyanine 7, APC-Cyanine 7 and a variety of other fluorophores. Recently, CBI has partnered with AAT Bioquest®, a producer of fluorescent labeling dyes to offer a unique high-performance solution for immunophenotyping and immunomonitoring.
iFluor™ Dyes iFluor™ dyes span the full UV-visible-IR spectrum. iFluor™ dyes have improved labeling performance compared to the classic fluorescent labeling dyes such as FITC, TRITC, Texas Red® and cyanine dyes
mFluor™ Dyes mFluor™ dyes span the full UV-visible spectrum and designed to be maximally excited by one of the major light sources in flow cytometers such as the violet laser at 405 nm or blue laser at 488 nm.
Monoclonal antibody design and development is lending researchers the opportunity to create highly specific, customizable mAbs for both RUO and ASR purposes. Start with a free consultation and let us take it to the step of your choosing.
Choose the production quantity that best meets your needs:From Idea to Antibody
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