BCMA PE
Catalog #
Size
Price
| Conjugation | PE |
|---|---|
| Antigen | BCMA |
| Clone | 22625B |
| Isotype | IgG1, k |
| Applications | FC |
| Reactivity | Human |
| Host | Mouse |
| Clonality | Monoclonal |
| Primary/Secondary | Primary |
| Format | 0.09% sodium azide, 0.2% BSA (w/v), PBS pH 7.2 |
| Storage | 2-8°C |
| Status | RUO |
| Excitation Laser | Yellow (561nm) |
Description:
BCMA (B cell maturation antigen), also known as CD269, is a ~27 kDa type III transmembrane glycoprotein encoded by the TNFRSF17 gene. It features a single TNFR-Cys repeat in its extracellular domain, followed by a transmembrane segment and a cytoplasmic tail that interacts with TRAF family proteins. CD269 is primarily expressed as a homotrimer on germinal center B cells, plasmablasts, and plasma cells, where it plays a critical role in the survival and maintenance of long-lived plasma cells.Its ligands, BAFF (CD257) and APRIL (CD256), activate intracellular signaling pathways essential for B cell maturation. CD269 is notably overexpressed in B cell malignancies, especially in multiple myeloma, and is implicated in autoimmune conditions such as systemic lupus erythematosus. Additionally, a soluble form of BCMA, produced by γ-secretase cleavage, can act as a decoy receptor to modulate the availability and signaling of its ligands, thereby influencing plasma cell differentiation and survival.
BCMA (B cell maturation antigen), also known as CD269, is a ~27 kDa type III transmembrane glycoprotein encoded by the TNFRSF17 gene. It features a single TNFR-Cys repeat in its extracellular domain, followed by a transmembrane segment and a cytoplasmic tail that interacts with TRAF family proteins. CD269 is primarily expressed as a homotrimer on germinal center B cells, plasmablasts, and plasma cells, where it plays a critical role in the survival and maintenance of long-lived plasma cells.Its ligands, BAFF (CD257) and APRIL (CD256), activate intracellular signaling pathways essential for B cell maturation. CD269 is notably overexpressed in B cell malignancies, especially in multiple myeloma, and is implicated in autoimmune conditions such as systemic lupus erythematosus. Additionally, a soluble form of BCMA, produced by γ-secretase cleavage, can act as a decoy receptor to modulate the availability and signaling of its ligands, thereby influencing plasma cell differentiation and survival.
From Idea to Antibody